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Across certain tumor types, immunotherapy has helped transform treatment for patients with cancer1

A graphic showing B- and T-cell checkpoint inhibitors.
  • T-cell checkpoint inhibitors have paved the way in immunotherapy by working in the adaptive immune system to effectively treat a number of solid tumors1
  • However, immunotherapies targeting the adaptive immune system have only created meaningful outcomes in limited types of liquid tumors so far1
  • A new class of immunotherapy that looks beyond traditional immune checkpoint inhibitors is needed

Is there more of the immune system left to unlock?

A graphic showing a macrophage.
  • Because higher-risk MDS cells can overexpress “don’t eat me” signals as a macrophage defense mechanism, research into phagocytic signals may lead to important discoveries in the ongoing case against HR-MDS2
  • Could research into decreasing the antiphagocytic CD47 signals expressed by malignant cells lead us to clues about HR-MDS?

Therapeutic advancement in HR-MDS has been limited in the last 15 years, leaving patients and physicians ill-equipped for far too long3,4

A graphic with an IV bag.
  • Hematopoietic stem cell transplantation (HSCT) is the only potentially curative option for patients with HR-MDS, but advanced age at diagnosis and comorbidities prevent a majority of patients with HR-MDS from receiving HSCT4

A graphic with the letters H, M, A, s which stand for Hypomethylating agents.
  • Hypomethylating agents (HMAs) are the current standard of care, but they fall short of generating complete responses in a majority of higher-risk patients4,5
    • Response rates to HMAs are limited. In a randomized, open-label, phase III study, ~30% of patients with HR-MDS achieved either a complete response or partial response, and ~50% of patients with HR-MDS achieved hematologic improvement. The primary endpoint, median overall survival, was ~2 years6
    • Real-world data suggest that median overall survival with HMAs in HR-MDS is shorter than the best clinical trial overall survival outcomes reported, which is ~2 years6,7
  • A lack of durable responses with current HMAs for HR-MDS makes relapse, progression to AML, and high transfusion burden likely3,4,8

Gilead is committed to the investigation.
Be sure to stay up to date as the case evolves.

for Updates

AML, acute myeloid leukemia; MDS, myelodysplastic syndrome.

  1. Salik B, Smyth MJ, Nakamura K. J Hematol Oncol. 2020;13(1):111. doi:10.1186/s13045-020-00947-6
  2. Swoboda DM, Sallman DA. Best Pract Res Clin Haematol. 2020;33(4):101221.
  3. Steensma DP. Blood Cancer J. 2018;8(5):47. doi:10.1038/s41408-018-0085-4
  4. Platzbecker U. Blood. 2019;133(10):1096-1107. doi:10.1182/blood-2018-10-844696
  5. Silverman LR, McKenzie DR, Peterson BL, et al. J Clin Oncol. 2006;24(24):3895-3903. doi:10.1200/JCO.2005.05.4346
  6. Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Lancet Oncol. 2009;10(3):223-232. doi:10.1016/S1470-2045(09)70003-8
  7. Zeidan AM, Stahl M, Sekeres MA, et al. Cancer. 2017;123(19):3662-3672. doi:10.1002/cncr.30903
  8. Bell JA, Galaznik A, Blazer M, et al. Leuk Lymphoma. 2019;60(1):49-59. doi:10.1080/10428194.2018.1464155