In higher-risk MDS, a mutated cell may overexpress CD47
CD47 is a checkpoint protein that sends an antiphagocytic, or “don’t eat me,” signal to the immune system.
Overexpressing CD47 suppresses phagocytosis and prevents macrophages from eliminating the mutated cell
Macrophages are part of the innate immune system. They play an important role in the clearance of malignant hematopoietic cells.
Preclinical data show that CD47 expression is greater in higher-risk MDS than low-risk MDS and may be even greater in AML than higher-risk MDS, making this a key area to focus on in the investigation1,3,4